There is mounting evidence implicating chronic systematic inflammation in osteoporosis and fracture risk in adults.

More than a dozen observational studies have explored the association of inflammatory markers (CRP, ILG, ILI, TNF) and osteoporosis. Subjects with the highest inflammatory burden have more than a threefold risk of hip fractures.

Recent research has also shown that ‘leaky-gut’ can explain rheumatoid arthritis due to the hyper-permeability when certain protein molecules are able to cross the mucosa and cross-react with the synovial membrane (molecular mimicry) to cause arthritis and a host of other chronic autoimmune diseases.